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Lupita kisses her boyfriend Jorge while her sister Olga cuts Jorge’s birthday cake at her home in Mexico City, Mexico on March 31, 2017. Maria Guadalupe Pilar Saucedo Granda, 43, and Jorge Antonio Moreno Gaytán, 34, both diagnosed with Prader-Willi syndrome, have been in a relationship for 11 years. They met at an annual meeting organized by the Mexican Prader-Willi Association Fundación María José in Pachuca, Mexico. They call each other daily but only see each other three to four times a year. They dream about getting married one day. Prader-Willi Syndrome (PWS) is a rare genetic disorder caused by an abnormality in chromosome 15. In newborns symptoms include weak muscle tone (hypotonia), poor appetite and slow development. In childhood the person experiences a sensation of constant hunger no matter how much he/she eats which often leads to obesity and Type 2 diabetes. There may also be mild to moderate intellectual impairment and behavioral problems. Physical characteristics include a narrow forehead, small hands and feet, short in stature, and light skin color. Prader-Willi syndrome has no known cure. However, with early diagnosis and treatment such as growth hormone therapy, the condition may improve. Strict food supervision is typically required. PWS affects an estimated 1 in 10,000 to 30,000 people worldwide. (Photo by Bénédicte Desrus)